Global Mindset
Language first, structure next
Single-country markets are too small and too volatile to carry a breakthrough venture. Build for a global market from day one: English as the working language, then international structures and early filings.
The rationale
The binding constraint is the market a single company actually sells into. Regional aggregates do not help a venture selling in one country: LATAM’s combined GDP is roughly US$6tn, and yet a venture serving one country faces a market that is neither large nor stable enough for a science-based business with a long development cycle, with currency volatility and rules that change at every border. Language compounds it. Founders who build in Spanish or Portuguese produce data rooms, technical documentation and contracts a foreign investor cannot read without friction, and diligence slows or stops there.
Two layers, in order. Make English the working language for pitch decks, data rooms, technical documentation and contracts, with ESOL upskilling aimed at the vocabulary founders actually use: IP and licensing terms, term sheets, regulatory and clinical or device documentation, and investor pitching, supported by English-ready data-room templates, bilingual model contracts and translation stipends. Then add structure: a holding company in a jurisdiction international investors already underwrite, such as Delaware, and early filings. One PCT application is recognised by 158 contracting states as of 1 June 2026, which buys time to nationalise later.
Half of this is not a founder decision. Only about 14 of 33 LATAM countries are PCT contracting states; Argentina, Bolivia, Paraguay and Venezuela are not, and Uruguay acceded at the end of 2023. A founder in Buenos Aires cannot use the PCT route at home, and accession is a sovereign act on a multi-year timetable. One editorial note for readers comparing this with the PDF: the report’s summary card prints USPTO and EPO while its chapter text specifies USPTO then PCT. The PCT is the route with treaty coverage behind it, and it is the version used here.
The evidence
What it unlocks
Diligence that clears on an English data room and a structure investors already underwrite, and a PCT route available in more than 14 of 33 countries.
It has been done before
Israel, building for export from a home market of ten million
Israel’s domestic market is smaller than any large LATAM economy, and its ventures were structured for foreign capital and foreign customers from inception. The 1993 Yozma program put US$100m into ten venture funds on a 40% public, 60% private split; on the IDB’s accounting the industry it seeded now manages over US$10bn and has generated more than US$80bn in value creation. A small home market did not cap the outcome once the structure was built outward.
First moves
- 0–6 months
Ship the English-ready artifact pack
Publish a bilingual pack, data-room index, model NDA and SAFE, IP assignment and technical summary template, in English alongside Spanish and Portuguese, and require an English data room for entry to regional pitch days.
LADP coalition secretariat + LAVCA + accelerators - 6–18 months
Fund ESOL and first filings as one instrument
Run a voucher covering targeted ESOL for founders and technical leads plus the first USPTO or PCT filing fees and attorney costs, capped per company and disbursed against a filing receipt.
CORFO, FINEP, ANPCyT, SECIHTI + national IP offices - 18–36 months
Move the non-member states toward PCT accession
Prepare an accession dossier for Argentina, Bolivia, Paraguay and Venezuela costing the fee schedule, national-phase workload and legislative steps, using Uruguay’s end-2023 accession as the worked template.
National IP offices + ministries of foreign affairs + WIPO + Mercosur and Pacific Alliance secretariats
How we would know it worked
- LATAM countries that are PCT contracting states, from the WIPO list, rising from 14 of 33.
- PCT applications with at least one LATAM-resident applicant, from WIPO annual statistics, rising year on year.
- Share of companies at regional pitch days presenting a complete English data room, counted per event, above 80%.
- Median time from first international investor meeting to term sheet, tracked quarterly by the observatory, falling below six months.
What could go wrong
Offshore holdcos read as capital flight
A Delaware parent moves the equity, the exit and often the tax base out of the country that funded the science, and public funders can reasonably object to subsidising that. Contain it by keeping R&D, payroll and IP-generating work in the local subsidiary under a documented cost-plus arrangement, and by writing that expectation into grant terms rather than banning offshore structures outright.
English-first used as a talent filter
If an English requirement lands before the upskilling exists, the region selects founders on schooling rather than on science and excludes the nontraditional-background technical talent it needs. Contain it by funding ESOL, translation stipends and bilingual templates before applying any English condition, and by keeping the technical evaluation itself in the applicant’s own language.
Who acts
Rests on
07 Uneven Clinical Trials Three routes out of a five-regulator patchwork
08 Regulatory Portability 33 countries, one optional 34th regime
10 Social Clusters Mixed cohorts and shared-service operators, with an anchor
03 Showcase & Visibility Educate privately, convene publicly
The data behind it
LATAM invests half of Europe’s level and a tenth of the United States’, per person, in USD.
As published in the report, September 2025.
SourcesLatin American Dynamism Project (LADP), Accelerating Deep Tech in Latin America; Inter-American Development Bank (IDB Lab), Deep Tech: The New Wave; Sling Hub & Itaú, LATAM Startup Market 2024 in Review; Atomico, State of European Tech Report 2024
Methodology: LADP calculation from cumulative regional deep tech investment ÷ population. ledger #67: denominators are inconsistent (Asia = continent, Europe ≈ EU). Recompute with stated population bases before refreshing.
| Category | Current |
|---|---|
| United States | $153 |
| Europe | $31 |
| Latin America | $15 |
| Asia | $3 |